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This Special Feature discusses the challenges associated with assessing changes in muscle mass that accompany GLP-1 drug-induced weight loss, the potential impact of muscle mass loss, and how to preserve muscle mass

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Evidence now shows that consistent weight loss occurs when GLP-1 therapy continues, with weight regain beginning 3 to 6 months after discontinuationunderscoring the importance of ongoing treatment strategies

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To assess the physiological importance of these FHA domain residues for cell viability and pre-mRNA splicing, we stably integrated F-SNIP1 constructs encoding WT or mutant SNIP1 into the FRT/TO integration site of the HCT116 dTAG SNIP1 cell line